CJC-1295 Without DAC (10mg)

Description

Product Overview: CJC-1295 Without DAC is a synthetic analog of Growth Hormone Releasing Hormone (GHRH), comprising the first 29 amino acids of GHRH with key amino acid substitutions at positions 2, 8, 15, and 27 to enhance stability against enzymatic degradation by dipeptidyl peptidase-IV (DPP-IV). Unlike the DAC (Drug Affinity Complex) variant, this form does not feature albumin-binding modification, resulting in a shorter duration of action that more closely mimics pulsatile GHRH release patterns. Research Profile: CJC-1295 Without DAC has been investigated in preclinical models for its effects on the somatotropic axis and downstream growth hormone-mediated processes. - GH secretion: Studied for its ability to stimulate pituitary somatotroph cells through GHRH receptor binding, promoting pulsatile growth hormone release patterns. - IGF-1 modulation: Examined for downstream effects on hepatic and peripheral IGF-1 production through GH-mediated JAK/STAT signaling pathways. - Pulsatile release dynamics: Investigated for its pharmacokinetic profile that supports natural GH pulse patterns, in contrast to continuous GH elevation observed with DAC-modified analogs. - Body composition: Explored in research models for effects on lean mass accretion and adipose tissue metabolism through GH/IGF-1 axis modulation. - Sleep architecture: Studied for its influence on slow-wave sleep patterns associated with GH release during nocturnal secretory episodes. Key Research Applications: CJC-1295 Without DAC serves as a valuable research tool in endocrinology and metabolic biology. - Somatotropic axis studies: Used to investigate GHRH receptor sensitivity and pituitary GH secretory capacity. - Metabolic research: Applied in models examining GH-mediated effects on glucose homeostasis and lipid metabolism. - Aging biology: Investigated for its capacity to restore diminished GH pulsatility associated with somatopause. - Comparative pharmacology: Utilized alongside DAC-modified variants to study the impact of albumin binding on peptide pharmacokinetics. Specifications: Peptide Content: 10mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls.