Mazdutide (100mg)

Description

Product Overview: Mazdutide is a synthetic dual-agonist peptide designed to activate both glucagon-like peptide-1 (GLP-1) and glucagon receptors. This dual-receptor engagement enables simultaneous investigation of complementary metabolic pathways: GLP-1 receptor-mediated insulinotropic and appetite-regulating effects alongside glucagon receptor-mediated hepatic glucose output and energy expenditure modulation. Mazdutide represents an important research tool for studying multi-target approaches to metabolic regulation. Research Profile: Mazdutide has been investigated in preclinical models for its dual-agonist pharmacology and effects on metabolic homeostasis. - GLP-1 receptor activation: Studied for its ability to stimulate insulin secretion in a glucose-dependent manner through GLP-1R-mediated cAMP signaling in pancreatic beta cells. - Glucagon receptor engagement: Examined for its effects on hepatic glycogenolysis, gluconeogenesis, and energy expenditure through glucagon receptor-mediated pathways. - Appetite regulation: Investigated for central effects on satiety through both GLP-1 and glucagon receptor pathways in hypothalamic feeding circuits. - Lipid metabolism: Explored for its effects on hepatic lipid oxidation and very-low-density lipoprotein (VLDL) production through glucagon receptor-mediated transcriptional programs. - Energy expenditure: Studied for its capacity to enhance thermogenesis and basal metabolic rate through glucagon-mediated activation of brown adipose tissue. Key Research Applications: Mazdutide serves as a dual-agonist research tool across metabolic and endocrine biology. - Metabolic disease models: Applied in glucose tolerance, lipid metabolism, and energy balance studies. - Dual-agonist pharmacology: Used to characterize the therapeutic window of concurrent GLP-1 and glucagon receptor activation. - Hepatic metabolism research: Investigated for effects on liver glucose and lipid homeostasis. - Body composition studies: Studied for effects on fat mass reduction and lean mass preservation through complementary receptor pathways. Specifications: Peptide Content: 100mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls.