GLP-3 RT (50mg)

Description

Product: GLP-3 RT (50mg) Product Overview: GLP-3 RT is a synthetic peptide analog engineered to interact with glucagon-like peptide receptor systems. Structurally related to endogenous incretin hormones, GLP-3 RT incorporates amino acid modifications designed to extend its stability profile and modulate receptor selectivity across GLP receptor subtypes. Supplied as a lyophilized powder, this compound serves as a research tool for investigating GLP receptor-mediated signaling, metabolic regulation, and neuroendocrine physiology. Research Profile: GLP-3 RT has been investigated in preclinical laboratory models for its receptor pharmacology and effects on metabolic and endocrine pathways. - GLP receptor binding kinetics: Studied for its binding affinity and selectivity toward GLP receptor subtypes using radioligand displacement assays and surface plasmon resonance techniques, with characterization of kon/koff rates and equilibrium dissociation constants. - cAMP signaling activation: Examined for its capacity to stimulate intracellular cAMP accumulation through Gs-protein-coupled receptor activation, measured via FRET-based biosensor assays and luciferase reporter systems in transfected cell lines. - Beta-cell secretory function: Investigated for its effects on glucose-dependent insulin secretion using isolated pancreatic islet preparations and perfused pancreas models, with assessment of first-phase and second-phase insulin release dynamics. - Gastric motility modulation: Explored for its influence on gastric emptying rates and intestinal transit time through vagal afferent and enteric nervous system pathways in ex vivo tissue preparations. - Hypothalamic satiety signaling: Studied for its central effects on anorexigenic neuropeptide expression (POMC, CART) and orexigenic pathway suppression (NPY, AgRP) in hypothalamic arcuate nucleus models. - Incretin axis pharmacology: Investigated as a tool compound for dissecting incretin receptor cross-talk and downstream signaling divergence between GLP-1R and related receptor subtypes. - Hepatic glucose output: Examined for its effects on hepatic gluconeogenesis and glycogenolysis through measurement of glucose-6-phosphatase and PEPCK expression in primary hepatocyte cultures. Key Research Applications: GLP-3 RT serves as a versatile research tool across metabolic, endocrine, and gastrointestinal biology. - Metabolic disease models: Applied in glucose tolerance studies, insulin clamp experiments, and hyperglycemic challenge procedures to characterize receptor-mediated metabolic effects. - Receptor structure-activity studies: Used in systematic SAR investigations comparing receptor activation profiles across GLP receptor agonist analogs. - Neuroendocrine circuit mapping: Investigated for its effects on hypothalamic-pituitary signaling and central regulation of energy balance. - Gastrointestinal physiology: Studied in models examining nutrient-stimulated hormone secretion, gut motility, and enteroendocrine cell function. - Comparative pharmacology: Employed alongside related agonists (semaglutide, liraglutide analogs) to benchmark receptor potency and signaling bias. Specifications: Peptide Content: 50mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls. Compliance Notice: For research use only. Not for human or animal consumption. Not intended for therapeutic or diagnostic use.