GDF-8 (1mg)

Description

Product Overview: GDF-8, also known as Myostatin, is a member of the transforming growth factor-beta (TGF-beta) superfamily that functions as a potent negative regulator of skeletal muscle growth. This secreted protein signals through activin type II receptors (ActRIIA/ActRIIB) and downstream Smad2/3 transcription factors to inhibit myoblast proliferation and differentiation, maintaining muscle homeostasis throughout development and adulthood. Research Profile: GDF-8 (Myostatin) has been extensively studied in laboratory models as a key regulator of muscle mass and metabolic function. - Muscle growth regulation: Investigated for its canonical role in limiting skeletal muscle hypertrophy through ActRIIB-mediated Smad2/3 signaling, suppressing MyoD and myogenin expression. - Myoblast biology: Studied for its inhibitory effects on satellite cell activation, proliferation, and terminal differentiation in muscle regeneration models. - Metabolic function: Examined for its influence on adipose tissue metabolism, insulin sensitivity, and energy expenditure beyond its primary role in muscle biology. - Fibrosis pathways: Explored for its contribution to fibrotic tissue deposition through TGF-beta pathway crosstalk in muscle and organ fibrosis models. - Knockout and inhibition studies: Used as a reference standard in loss-of-function experiments to validate myostatin inhibitor efficacy. Key Research Applications: GDF-8 is utilized as both a signaling molecule and a reference standard across musculoskeletal and metabolic research. - Muscle wasting models: Applied as a recombinant ligand to study catabolic muscle loss and evaluate countermeasures. - Receptor binding assays: Used in biochemical studies to characterize ActRIIB binding kinetics and inhibitor screening. - Metabolic disease research: Investigated for its systemic effects on glucose disposal and fat metabolism. - Developmental biology: Studied for its role in embryonic myogenesis and post-natal muscle growth regulation. Specifications: Content: 1mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls.