ARA-290 (10mg)

Description

Product Overview: ARA-290 is a synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO). It is designed to selectively interact with the innate repair receptor (IRR), a heterodimer composed of the EPO receptor and the beta common receptor (CD131), without activating classical erythropoietic pathways. This selectivity makes ARA-290 a valuable research tool for studying tissue-protective and anti-inflammatory signaling independent of erythropoiesis. Research Profile: ARA-290 has been studied in preclinical models for its cytoprotective and anti-inflammatory properties mediated through IRR activation. - Innate repair receptor activation: Investigated for its selective binding to the EPO-R/CD131 heterodimer, activating Jak2/STAT5 and PI3K/Akt survival pathways without stimulating red blood cell production. - Neuroprotective effects: Examined in neuronal injury models for its ability to attenuate apoptosis and promote neural cell survival through anti-inflammatory signaling cascades. - Anti-inflammatory activity: Studied for its capacity to reduce pro-inflammatory cytokine release (TNF-alpha, IL-6) and modulate macrophage polarization toward reparative phenotypes. - Tissue repair: Explored for its effects on wound healing, corneal nerve regeneration, and small fiber neuropathy models. - Metabolic neuropathy: Investigated for potential protective effects on peripheral nerve fibers in models of metabolic-induced nerve damage. Key Research Applications: ARA-290 is utilized across neuroscience, immunology, and tissue repair research domains. - Neuropathy models: Applied in studies examining small fiber nerve regeneration and functional recovery. - Inflammatory disease models: Used to evaluate tissue-protective signaling in inflammatory conditions. - Ophthalmological research: Studied for effects on corneal nerve density and tear production in dry eye models. - Cardiac tissue protection: Investigated for cytoprotective effects in ischemia-reperfusion injury models. Specifications: Peptide Content: 10mg per vial Appearance: Lyophilized powder Storage & Handling: Store in a cool, dry environment protected from light and moisture. Reconstitution and handling should be performed using standard laboratory procedures and appropriate laboratory controls.